Etacrynic acid

CAS No. 58-54-8

Etacrynic acid( Edecrin )

Catalog No. M15149 CAS No. 58-54-8

A loop diuretic used to treat high blood pressure and the swelling, a novel ligand and inhibitor of MAP2K6 kinase that inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
25MG 28 In Stock
50MG 41 In Stock
100MG 70 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Etacrynic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    A loop diuretic used to treat high blood pressure and the swelling, a novel ligand and inhibitor of MAP2K6 kinase that inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue.
  • Description
    A loop diuretic used to treat high blood pressure and the swelling, a novel ligand and inhibitor of MAP2K6 kinase that inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue; shows anticancer activity, and also is a potent inhibitor of glutathione S-transferase; shows antitumor effects and may enhance the cytotoxicity of chemotherapeutic agents by binding to glutathione and inhibiting WNT signaling.Other Indication Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Edecrin
  • Pathway
    MAPK/ERK Signaling
  • Target
    MEK
  • Recptor
    NKCC2|GST
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    58-54-8
  • Formula Weight
    303.135
  • Molecular Formula
    C13H12Cl2O4
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 30 mg/mL; DMSO: 30 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    CCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl
  • Chemical Name
    Acetic acid, [2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]- (9CI)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chan AI, et al. J Am Chem Soc. 2017 Aug 2;139(30):10192-10195. 2. Wang R, et al. Clin Cancer Res. 2012 Dec 15;18(24):6690-701. 3. Bryant ZE, et al. Bioorg Med Chem Lett. 2011 Feb 1;21(3):912-5. 4. Liu B, et al. Oncotarget. 2016 Sep 6;7(36):58038-58050.
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