Etacrynic acid
CAS No. 58-54-8
Etacrynic acid( Edecrin )
Catalog No. M15149 CAS No. 58-54-8
A loop diuretic used to treat high blood pressure and the swelling, a novel ligand and inhibitor of MAP2K6 kinase that inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 28 | In Stock |
|
| 50MG | 41 | In Stock |
|
| 100MG | 70 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameEtacrynic acid
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NoteResearch use only, not for human use.
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Brief DescriptionA loop diuretic used to treat high blood pressure and the swelling, a novel ligand and inhibitor of MAP2K6 kinase that inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue.
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DescriptionA loop diuretic used to treat high blood pressure and the swelling, a novel ligand and inhibitor of MAP2K6 kinase that inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue; shows anticancer activity, and also is a potent inhibitor of glutathione S-transferase; shows antitumor effects and may enhance the cytotoxicity of chemotherapeutic agents by binding to glutathione and inhibiting WNT signaling.Other Indication Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsEdecrin
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PathwayMAPK/ERK Signaling
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TargetMEK
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RecptorNKCC2|GST
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number58-54-8
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Formula Weight303.135
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Molecular FormulaC13H12Cl2O4
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Purity>98% (HPLC)
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SolubilityEthanol: 30 mg/mL; DMSO: 30 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESCCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl
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Chemical NameAcetic acid, [2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]- (9CI)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chan AI, et al. J Am Chem Soc. 2017 Aug 2;139(30):10192-10195.
2. Wang R, et al. Clin Cancer Res. 2012 Dec 15;18(24):6690-701.
3. Bryant ZE, et al. Bioorg Med Chem Lett. 2011 Feb 1;21(3):912-5.
4. Liu B, et al. Oncotarget. 2016 Sep 6;7(36):58038-58050.
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